Preprint

• Qizheng Zhang, Sona Rani Roy, Tianrui Zhao, Wenjing Hou, Chenjie Xu, Jiancan Yu, Kai Wu, Xunwu Hu*, Ye Zhang(* "Integrin-engaged Cellular Patches Mechanically Impose a MItochondrial Respiratory Bottleneck to Suppress Cancer Cell Motility" https://www.biorxiv.org/cgi/content/short/2026.07.03.736349v1
• Junchao Zhi, Tianrui Zhao, Wenjing Hou, Qizheng Zhang, Zhen Gao, Jiancan Yu, Kai Wu, Chenjie Xu, Xunwu Hu*, Ye Zhang* "Engineering Apical Integrin-binding Cellular Patches to Direct Cell Reprogramming via Mechanical Remodeling" https://www.biorxiv.org/content/10.1101/2025.11.21.689608v1

• Ziyi Su, Yanling Lin, Zhu Zhu, Xiaoqing Li, Wenjing Hou, Qizheng Zhang, Yanbin Cai, Jie Gao, Zhimou Yang, Ye Zhang, Xunwu Hu "Terminal Modification Reprograms Supramolecular Organization of Integrin Ligand Assemblies to Shape Cell Migration" https://www.biorxiv.org/content/10.64898/2026.09.29.755244v1

2026

• Junchao Zhi, Tianrui Zhao, Wenjing Hou, Qizheng Zhang, Zhen Gao, Jiancan Yu, Kai Wu, Chenjie Xu, Xunwu Hu*, Ye Zhang* "Engineering Apical Integrin-binding Cellular Patches to Direct Cell Reprogramming via Mechanical Remodeling" ACS Nano, 2026, 20, 24, 17536-17549.

2025

• Xueyan Wang, Yayi Zhao, Xingtao Huang, Yu Huang, Ye Zhang, Chenjie Xu* "Influence of Polyethylene glycol on the mucus penetration and stability of lipid nanoparticles in Cryoreservation and Lyophilization" RSC Advances, 2025, 15, 40279-40285.
• Tantan Yang, Zhuofeng Li, Ting Liang,* Qizheng Zhang, Xunwu Hu, Peng Wang, Zhuo Zeng,* Ye Zhang* "Engineering a Viscosity-Gated Dual-Rotor Probe for Comprehensive Mapping of Lipid Droplet Heterogeneity" ACS Sensors, 2025, 10, 9, 6406-6414.
• Beibei Zhang, Junchao Zhi, Huilin Wei, Qizheng Zhang, Enming Du, Ting Liang, Xunwu Hu,* Chengzhi Jin,* Ye Zhang* "Enzyme-Responsive Assembly of Cysteine-Terminated Heparan Sulfate Proteoglycan Ligands for Osteoinductive Biphasic Scaffold Formation" ACS Materials Letters, 2025, 7, 8, 3017-3025. 
• Yayi Zhao, Qizheng Zhang, Tianli Hu, Chaiyaporn Kuwentrai, Ye Zhang, Jian-Dong Huang, Yi Kuang, Chenjie Xu* "Optimization of Dissolvable Lipid Nanoparticle Microneedle Formulation for mRNA Delivery Using Design of Experiments" ACS Applied Materials & Interfaces, 2025, 17, 29, 41597-41609. 
• Liang Shao, Lulu Yang, Jiaqi Song, Hongwen Yu, Caiting Meng, Wanglin Duan, Xinling Liu, Xuxu Chen, Shuichu Hao, Ye Zhang, Chun Zhang,* Shichang Liu,* Guanying Li* "Engineering natural arginine finger to deliver phosphate-containing drugs for treating osteoarthritis" Chemical Engineering Journal, 2025, 518, 164353.
• Yonghui Zhang, Huili Liang, Xuefeng Cai, Rui Zhu, Ye Zhang, Qing Lu, Zengxia Mei* "Transition-Rule Defined Polarization Detection of β-Ga₂O₃ for Wavelength-Dependent Sensing of Amino Acid" Laser & Photonics Reviews, 2025, e00844. 
• Longzhen Chen, Zhuofeng Li, Ziyi Su, Yuqi Luo,* Xunwu Hu,* Ye Zhang* "Engineering Heparan Sulfate-Guided Peptide Self-Assembly to Restore Endothelial Angiogenesis Under Hyperglycemia" ACS Biomaterials Science & Engineering, 2025, 11, 7, 4504-4514.
• Yanglin Jiang, Qizheng Zhang, Xunwu Hu, Ting Liang, Ailin Sun, Chenjie Xu, Peng Wang,* Ye Zhang* "Fluorogenic Crystallization via Enzyme-Instructed Excited-State Intramolecular Proton Transfer for Dynamic Microenvironment Profiling" ACS Sensors, 2025, 10, 3, 2287-2296.
• Caiting Meng, Shuajun Li, Yana Ma, Hongwei Yu, Jiaqi Song, Junchao Zhi, Bin Zhu, Liang Shao, Xinling Liu, Lulu Yang, Mingzhen Zhang,* Ye Zhang,* Guangying Li* "Assembling Ruthenium Complexes to Form Ruthenosome Unleashing Ferritinophagy-mediated Tumor Suppression" ACS Nano, 2025, 19, 10, 10207-10219.

2024

• Yazhou Chen, Qizheng Zhang, Shenyu Yang, Guanying Li, Chaochen Shi, Xunwu Hu, Shunsuke Asahina, Natsuko Asano, Ye Zhang* “Formulate Adaptive Biphasic Scaffold via Sequential Protein-Instructed Peptide-Co-Assembly ” Advanced Science, 2024, 11(29):e2401478.

2023

• Xianpeng Zhang, Xinling Liu, Hongwen Yu, Shuang Shen, Junchao Zhi, Zhen Gao, Jingqi Xin, Jiaqi Song, Liang Shao, Caiting Meng, Feifei An, Taotao Huo, Shichuang Liu,* Ye Zhang, Li Xu,* Guanying Li* “Bone analysis using an aggregation-induced emission-active iridium complex ” Aggregate, 2023, e381

2022

• Xunwu Hu, Sona Rani Roy, Chengzhi Jin, Guanying Li, Qizheng Zhang, Natsuko Asano, Shunsuke Asahina, Tomoko Kajiwara, Atsushi Takahara, Bolu Feng, Kazuhiro Aoki, Cehnjie Xu, Ye Zhang* “Control Cell Migration by Engineering Integrin Ligand Assembly” Nature Communications, 2022, 13:5002
• Jiaqi Song, Qizheng Zhang, Guanying Li,* Ye Zhang* "Constructing ECM-like Structure on the Plasma Membrane via Peptide Assembly to Regulate the Cellular Response", Langmuir, 2022, 38, 8733-8747.
• Enming Du, Yunlan Tang, Qizheng Zhang, Zongming Song,* Ye Tao,* and Ye Zhang* “Enhancing the Cellular Uptake of Macromolecules via Enzyme-Instructed Self-Assembly”, Langmuir, 2022, 38, 4364-4370
• Liang Shao, Shichang Liu, Guanying Li,* Ye Zhang* “Capture Phosphates via Peptide Self-assembly to Construct Templates Assisting Mineralization” ChemNanoMat, 2022, 8, e202100542.

2021

• Xunwu Hu, Ye Zhang* “Developing Biomaterials to Mediate the Spatial Distribution of Integrins” Biophysics Reviews, 2021, 2, 041302.
• Dingze Mang, Sona Rani Roy, Qizheng Zhang, Xunwu Hu, Ye Zhang*“Heparan-Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration” ACS Applied Materials & Interfaces, 2021, 13, 17236-17242.

• Guanying Li, Xunwu Hu, Xia Wu, Ye Zhang* “Microtubule-Targeted Self-Assembly Triggers Prometaphase-Metaphase Oscillations Suppressing Tumor Growth” Nano Letters, 2021, 21, 3052-3059.

• Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Toshio Sasaki, Hui Chao,* and Ye Zhang* “Robust Packing of a Self-Assembling Iridium Complex via Endocytic Trafficking for Long-term Lysosome Tracking” Angew. Chem. Int. Ed., 2021, 60, 7597-7601.
• Guanying Li, Xunwu Hu, Pingping Nie, Dingze Mang, Shi Jiao, Shijin Zhang, Sona Rani Roy, Sachie Yukawa, Shunsuke Asahina, Hiroaki Sugasawa, William Cortes, Zhaocai Zhou* and Ye Zhang* “Lipid-raft-targeted Molecular Self-assembly Inactivates YAP to Suppress Ovarian Cancer Growth” Nano Letters, 2021, 21, 747-755.
• Xia Wu, Xunwu Hu, Ye Zhang* “Regulate Cellular Responses via Molecular Assembly in Cell Milieu for Cancer Therapy” Chemistry Letters, 2021, 50 (Commemorative Highlight Review), 405-410.

2020

• Guanying Li, William Cortes, and Ye Zhang* “Chemical Oscillation and Morphological Oscillation in Catalyst-embeded Lyotropic Liquid Crystalline Gels” Frontiers in Chemistry, (invited contribution), 2020, (doi.org/10.3389/fchem.2020.583165).
• Shijin Zhang, and Ye Zhang* “Promote Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly” ACS Applied Materials & Interfaces, 2020, 37, 41105-41112.
• Jiaqing Wang, Weiyi Tan, Guanying Li, Difei Wu, Hongjian He, Jiashu Xu, Meihui Yi, Ye Zhang, S. Ali Aghvami, Seth Fraden, Bing Xu* “Enzymatic Insertion of Lipids Increases Membrane Tension for Inhibiting Cancer Cells” Chem. Eur. J. 2020, 26, 15116-15120.
• Shijin Zhang, William Cortes, and Ye Zhang* “Constructing Cross-linked Nanofibrous Scaffold via Dual-Enzyme-Instructed Hierarchial Assembly” Langmuir, 2020, 36, 6261-6267.
• Sona Rani Roy, Guanying Li, Xunwu Hu, Shijin Zhang, Sachie Yukawa, Enming Du, and Ye Zhang* “Integrin and Heparan Sulfate Dual-targeting Peptide Assembly Suppresses Cancer Metastasis” ACS Applied Materials & Interfaces, 2020, 17, 19277-19284.
• Dingze Mang, Sona Rani Roy, Hong Huat Hoh, Xia Wu, Jiahao Zhang, Chengzhi Jin, and Ye Zhang* “Self-Assembly of Integrin Ligands on the Apical Membrane Inhibits the Migration of Glioma Cells” Langmuir, 2020, 14, 3750-3757.
• Shijin Zhang, William Cortes, Toshio Sasaki, Shunsuke Asahina, Asano Natsuko, Qizheng Zhang, and Ye Zhang* "Mechanoresponsive Alignment of Molecular Self-assembled Negatively Charged Nanofibrils" ACS Applied Bio Materials. 2020, 3, 1698-1704.

2019

• Shijin Zhang, Xunwu Hu, Dingze Mang, Toshio Sasaki, and Ye Zhang* "Self-delivery of N-hydroxylethyl Peptide Assemblies to the Cytosol Inducing Endoplasmic Reticulum Dilation in Cancer Cells "  Chem. Commun. 2019, 55, 7474-7477.
• Enming Du, Xunwu Hu, Guanying Li, Shijin Zhang, Dingze Mang, Sona Roy, Toshio Sasaki, and Ye Zhang* "Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Ananlogues for Permeability Alteration" Langmuir, 2019, 35, 7376 - 7382.

2018

• Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kunichi Miyazawa, and Ye Zhang* "Regulate Higher-order Organization through the Synergy of Two Self-sorted Assemblies" Angew. Chem. Int. Ed. 2018, 57, 3636-3640.

2017

• Wei Ji, Shijin Zhang, Gerogy A. Filonenko, Guanying Li, Toshio Sasaki, Chuanliang Feng* and Ye Zhang* "Co-Organizing Synthesis of Heterogeneous Nanostructure through Photo-Cleavage of Pre-Stabilized Self-Assemblies"  Chem. Commun. 2017, 53, 4702-4705.
• Guanying Li, Toshio Sasaki, Shunsuke Asahina, Michael C. Roy, Toshiaki Mochizuki, Koji Koizumi, and Ye Zhang*“Patching of Lipid Rafts by Molecular Self-Assembled Nanofibrils Suppresses Cancer Cell Migration” Chem. 2017, 2, 283-298.
• Enming Du, Xunwu Hu, Sona Roy, Peng Wang, Kieran Deasy, Toshiki Mochizuki and Ye Zhang* "Taurine-Modified Ru(II)-Complex Targets Cancerous Brain Cells for Photodynamic Therapy”, Chem. Commun. 2017, 53, 6033-6036.

2016 & before

• Yunhui Zheng.; Guanying Li; Ye Zhang* "Organometallic Hydrogels" ChemNanoMat, 2016, 2, 364-375.
• Qingcong Wei, Mengchi Xu, Chuanan Liao, Qing Wu, Mingyu Liu, Ye Zhang*, Chengtie Wu*, Qigang Wang* "Printable hybrid hydrogel by dual enzymatic polymerization with superactivity" Chemical Science, 2016,7, 2748.

• Ye Zhang; Zhou, N.; Shi, J. F.; Pochapsky, S. S.; Pochapsky, T. C.; Zhang, B.; Zhang, X. X.; Xu, B.^* “Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” Nature Commun. 2015, 6, 6165.
• Shi, J. F.; Du, X. W.; Huang, Y. B.; Zhou, J.; Yuan, D.; Wu, D. D.; Ye Zhang; Haburcak, R.; Eptein, I. R.^*; Xu, B.^* “Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules to Induce Cell Necroptosis” J. Am. Chem. Soc. 2015, 137, 26-29.
• Park, S.; Kim, D.; Ko, S. Y.; Park, J-O., Akella S., Xu, B., Ye Zhang; Fraden, S.^* “Controlling uniformity of photo-polymerized microscopic hydrogels” Lab on a Chip. 2014, 14, 1551-1563.
• Ye Zhang; Zhou, N.; Kim, D.; Fraden, S.*; Epstein, I. R.*; Xu, B.* “Giant Volume Change of Active Gels under Continuous Flow” J. Am. Chem. Soc., 2014, 136, 7341-7347.
• Ye Zhang; Zhou, N.; Akella, S.; Kuang, Y.; Kim, D.; Schwartz, A.; Bezpalko, M.; Foxman, B. M.; Fraden, S.; Epstein, I. R.^*; Xu, B.^* “Active Cross-linkers that Lead to Active Gels” Angew. Chem. Int. Ed. 2013, 52, 11494-11498.
• Ye Zhang; Zhou, R.; Shi, J.; Zhou, N.; Epstein, I. R.; Xu, B.^* “Post-Self-Assembly Cross-Linking to Integrate Molecular Nanofibers with Copolymers in Oscillatory Hydrogels” J. Phys. Chem. B, 2013, 117, 6566-6573.
• Ye Zhang; Zhang, B.; Kuang, Y.; Gao, Y.; Shi, J.; Zhang, X. X.; Xu, B.^* “A Redox Responsive, Fluorescent Supramolecular Metallohydrogel Consists of Nanofibers with Single-Molecule Width” J. Am. Chem. Soc., 2013, 135, 5008-5011.
• Kuang, Yi.; Yuan, D.; Ye Zhang; Du, X. W.; Xu, B.^* “Interactions between cellular proteins and morphologically different nanoscale aggregates of small molecules” RSC Advances, 2013, 3, 7704-7707.
• Yang, Z. M.; Kuang, Y.; Li, X. M.; Zhou, N.; Ye Zhang; Xu, B.^* “Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA” Chem. Commun. 2012, 48, 9257-9259.
• Ye Zhang; Li, N.; Delgado, J.; Zhou, N.; Yoshida, R.; Fraden, S.; Epstein, I. R.^*; Xu, B.^* “Structural modulation of self-oscillating gels: Changing the proximity of the catalyst to the polymer backbone to tailor chemomechanical oscillation” Soft Matter, 2012, 8, 7056-7061.
• Ye Zhang; Li, N.; Delgado, J.; Gao, Y.; Kuang, Y.; Fraden, S.; Epstein, I. R.^*; Xu, B.^* “Post-Self-Assembly Crosslinking of Molecular Nanofibers for Oscillatory Hydrogels” Langmuir, 2012, 28, 3063-3066.
• Delgado, J.; Ye Zhang; Xu, B.; Epstein, I. R. “Terpyridine- and Bipyridine-Based Ruthenium Complexes as Catalysts for the Belousov-Zhabotinsky Reaction” J. Phys. Chem. A, 2011, 115, 2208-2215.
• Shi, J. F.; Gao, Y.; Ye Zhang; Pan, Y.; Xu, B.^* “Calcium Ions to Crosslink Supramolecular Nanofibers to Tune the Elasticity of Hydrogels over Orders of Magnitude” Langmuir, 2011, 27, 14425-14431.
• Ye Zhang; Yousef, Y. A.; Li, H.; Melø, T. B.; Naqvi, K. R.^* “Comparison of the photochemical behaviors of α-tocopherol and its acetate in organic and aqueous micellar solutions” J. Phy. Chem. A. 2011, 29, 8242-8247.
• Ye Zhang, Yi Kuang, Yuan Gao, Bing Xu^* “Versatile Small Molecule Motifs for Self-assembly in Water and Formation of Biofunctional Supramolecular Hydrogels” Langmuir, 2011, 27, 529-537.
• Yuan Gao, Fan Zhao, Qi Wang, Ye Zhang, Bing Xu^* “Small Peptide Nanofibers as the Matrices of Molecular Hydrogels for Mimicking Enzymes and Enhancing the Activity of Enzymes” Chem. Soc. Rev. 2010, 39, 3425-3433.
• Dai, W-M.^*; Li, Y.; Ye Zhang; Yue, C.; Wu, J. “Generation of an Aromatic Amide-Derived Phosphane (Aphos) Library by Self-Assisted Molecular Editing and Applications of Aphos in Room-Temperature Suzuki-Miyaura Reactions” Chem. Eur. J. 2008, 14, 5538-5554.
• Dai, W-M.^*; Ye Zhang. “A Family of Simple Amide-Derived Air-Stable P, O-Ligands for Suzuki Cross-Coupling of Unactivated Aryl Chlorides” Tetrahedron Lett. 2005, 46, 1377-1381.
• Dai, W-M.^*; Li, Y.; Ye Zhang; Lai, K. W.; Wu, J. “A Novel Class of Amide-Derived Air-Stable P, O-Ligands for Suzuki Cross-Coupling at Low Catalyst Loading” Tetrahedron Lett. 2004, 45, 1999-2001.
• W-M.^*; Zhang, Y.; Ye Zhang. “Synthesis of Atropisomeric 2,8-Dioxygenated N, N-Diisopropyl-1-naphthamides via Kinetic Resolution under the Sharpless Asymmetric Dihydroxylation Conditions” Tetrahedron: Asymmetry 2004, 15-525-535.
• Dai, W-M.^*; Yeung, K. Y.; Liu, J-T.; Ye Zhang; Williams, I. D. “A Novel Class of Nonbiaryl Atropisomeric P, O-Ligands for Palladium-Catalyzed Asymmetric Allylic Alkyation” Org. Lett. 2002, 4, 1615-1618.